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Hiroyuki Tsuchiya Selected Research

Caffeine (No Doz)

2/2020Exquisite Tumor Targeting by Salmonella A1-R in Combination with Caffeine and Valproic Acid Regresses an Adult Pleomorphic Rhabdomyosarcoma Patient-Derived Orthotopic Xenograft Mouse Model.
9/2019Oral Recombinant Methioninase, Combined With Oral Caffeine and Injected Cisplatinum, Overcome Cisplatinum-Resistance and Regresses Patient-derived Orthotopic Xenograft Model of Osteosarcoma.
7/2019Caffeine citrate enhanced cisplatin antitumor effects in osteosarcoma and fibrosarcoma in vitro and in vivo.
10/2018Oral Recombinant Methioninase Combined with Caffeine and Doxorubicin Induced Regression of a Doxorubicin-resistant Synovial Sarcoma in a PDOX Mouse Model.
1/2017Antimetastatic Efficacy of the Combination of Caffeine and Valproic Acid on an Orthotopic Human Osteosarcoma Cell Line Model in Nude Mice.
1/2017Efficacy In Vitro of Caffeine and Valproic Acid on Patient-Derived Undifferentiated Pleomorphic Sarcoma and Rhabdomyosarcoma Cell Lines.
1/2016Non-toxic Efficacy of the Combination of Caffeine and Valproic Acid on Human Osteosarcoma Cells In Vitro and in Orthotopic Nude-mouse Models.
11/2013Dynamic color-coded fluorescence imaging of the cell-cycle phase, mitosis, and apoptosis demonstrates how caffeine modulates cisplatinum efficacy.
2/2013Caffeine-potentiated chemotherapy for clear cell sarcoma: a report of five cases.
9/2012Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-κB and MAPK pathways.
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Hiroyuki Tsuchiya Research Topics

Disease

238Neoplasms (Cancer)
08/2022 - 08/2002
81Osteosarcoma (Osteogenic Sarcoma)
02/2022 - 07/2002
72Neoplasm Metastasis (Metastasis)
08/2022 - 08/2002
56Sarcoma (Soft Tissue Sarcoma)
03/2022 - 01/2003
31Infections
01/2022 - 01/2003
26Congenital Abnormalities (Deformity)
08/2020 - 09/2002
23Pain (Aches)
08/2022 - 08/2011
18Fibrosarcoma
02/2020 - 01/2003
13Wounds and Injuries (Trauma)
06/2022 - 07/2009
13Hepatocellular Carcinoma (Hepatoma)
01/2022 - 06/2008
10Osteoarthritis
07/2022 - 03/2014
8Necrosis
09/2021 - 11/2002
8Giant Cell Tumors (Giant Cell Tumor)
01/2021 - 09/2006
8Pancreatic Neoplasms (Pancreatic Cancer)
03/2019 - 04/2009
7Disease Progression
06/2022 - 05/2011
7Thyroid Neoplasms (Thyroid Cancer)
06/2022 - 02/2011
7Synovial Sarcoma (Synovioma)
07/2021 - 09/2012
7Renal Cell Carcinoma (Grawitz Tumor)
06/2021 - 09/2011
7Osteomyelitis
04/2021 - 01/2003
7Insulin Resistance
05/2014 - 01/2011
6Non-alcoholic Fatty Liver Disease
11/2016 - 06/2010
5Paralysis (Palsy)
08/2022 - 01/2003
5Liver Diseases (Liver Disease)
06/2022 - 12/2006
5Surgical Wound Infection
01/2022 - 11/2013
5Iron Overload
01/2022 - 12/2010
5Margins of Excision
09/2021 - 01/2005
5Giant Cell Tumor of Bone
07/2020 - 09/2006
5Spinal Cord Diseases
06/2020 - 08/2013
4Carcinoma (Carcinomatosis)
01/2021 - 05/2005

Drug/Important Bio-Agent (IBA)

35NitrogenIBA
02/2021 - 01/2003
28Doxorubicin (Adriamycin)FDA LinkGeneric
12/2021 - 11/2002
27Green Fluorescent ProteinsIBA
01/2017 - 01/2003
23TESIBA
12/2021 - 02/2011
22Proteins (Proteins, Gene)FDA Link
12/2021 - 11/2003
22Caffeine (No Doz)FDA LinkGeneric
02/2020 - 11/2002
22Red Fluorescent ProteinIBA
11/2016 - 01/2003
18Biological ProductsIBA
02/2021 - 01/2006
17Pharmaceutical PreparationsIBA
12/2021 - 01/2003
13IodineIBA
07/2021 - 09/2012
13Cisplatin (Platino)FDA LinkGeneric
01/2021 - 11/2002
12L-methionine gamma-lyaseIBA
05/2020 - 06/2003
12RetinoidsIBA
05/2018 - 12/2006
10TitaniumIBA
07/2021 - 10/2009
9IntegrinsIBA
01/2019 - 11/2012
8Therapeutic UsesIBA
01/2022 - 07/2005
7pazopanibFDA Link
09/2021 - 01/2017
7Methionine (L-Methionine)FDA Link
03/2021 - 06/2003
7Messenger RNA (mRNA)IBA
10/2019 - 02/2008
6LigandsIBA
01/2022 - 11/2005
6Reactive Oxygen Species (Oxygen Radicals)IBA
01/2022 - 06/2003
6IronIBA
01/2022 - 01/2009
6Temozolomide (Temodar)FDA LinkGeneric
12/2021 - 09/2017
6IfosfamideFDA LinkGeneric
01/2021 - 11/2013
5CollagenIBA
06/2022 - 08/2013
5calcium phosphateIBA
02/2022 - 01/2011
5DenosumabFDA Link
01/2022 - 01/2017
5Irinotecan (Camptosar)FDA LinkGeneric
12/2021 - 03/2007
5Anti-Bacterial Agents (Antibiotics)IBA
04/2021 - 10/2014
5GemcitabineFDA Link
07/2020 - 03/2011
5Tretinoin (Retinoic Acid)FDA LinkGeneric
11/2013 - 06/2010
5Histones (Histone)IBA
01/2012 - 06/2004
4cytidylyl-(3'-5')-cytidine (CpC)IBA
02/2022 - 01/2011
4Antineoplastic Agents (Antineoplastics)IBA
01/2022 - 09/2005
4Eosine Yellowish-(YS) (Eosin)IBA
01/2022 - 12/2012
4Immune Checkpoint InhibitorsIBA
01/2022 - 01/2019
4TrabectedinIBA
12/2021 - 09/2017
4palbociclibIBA
12/2021 - 12/2018
4Sorafenib (BAY 43-9006)FDA Link
12/2021 - 08/2019
4olaratumabIBA
12/2021 - 01/2019

Therapy/Procedure

83Drug Therapy (Chemotherapy)
03/2022 - 08/2002
55Therapeutics
06/2022 - 01/2003
19Osteotomy
10/2021 - 09/2002
18Radiotherapy
06/2022 - 02/2007
16Hip Replacement Arthroplasty (Total Hip Replacement)
11/2022 - 08/2011
16Distraction Osteogenesis
03/2022 - 07/2002
15Curettage
04/2022 - 07/2002
13Operative Surgical Procedures
03/2022 - 01/2013
13Immunotherapy
01/2022 - 05/2010
11Metastasectomy
06/2022 - 08/2002
11External Fixators
09/2019 - 09/2005
10Neoadjuvant Therapy
04/2021 - 07/2008
8Arthrodesis
07/2022 - 01/2003
8Operative Time
06/2022 - 08/2013
8Conservative Treatment
01/2022 - 12/2012
7Aftercare (After-Treatment)
01/2021 - 01/2015
7Spinal Fusion (Spondylosyndesis)
06/2020 - 09/2013
6Knee Replacement Arthroplasty (Total Knee Replacement)
02/2022 - 09/2011
6Limb Salvage
11/2020 - 05/2010
6Decompression
01/2020 - 07/2002
5Palliative Care (Palliative Therapy)
08/2022 - 04/2006
5Orthopedic Procedures
07/2022 - 09/2012
5Surgical Amputation (Amputations)
04/2022 - 10/2011
5Bone Transplantation (Bone Grafting)
04/2022 - 01/2003
5Reoperation
09/2020 - 08/2011
5Activities of Daily Living (ADL)
08/2020 - 09/2013
5Laminoplasty
06/2020 - 08/2013
4Debridement
06/2022 - 01/2014
4Arthroplasty
01/2022 - 05/2010
4Prostheses and Implants (Prosthesis)
01/2021 - 09/2012
4Anterior Cruciate Ligament Reconstruction
12/2020 - 12/2012